Newsletter
Language
Language:
 
News
Archival Issues
Volume 19, 2017
Volume 18, 2016
Volume 17, 2015
Volume 16, 2014
Volume 15, 2013
Volume 14, 2012
Volume 13, 2011
Volume 12, 2010
Volume 11, 2009
Volume 10, 2008
Volume 9, 2007
Volume 8, 2006
Volume 7, 2005
Volume 6, 2004
Volume 5, 2003
Volume 4, 2002
Volume 3, 2001
Volume 2, 2000
Volume 1, 1999
Search
 » 
Journal Abstract
 
Fracture Healing and its Disturbances. A literature Review
Grzegorz Szczęsny
Ortop Traumatol Rehabil 2015; 17(5):437-454
ICID: 1186809
Article type: Review article
IC™ Value: 2.40
Abstract provided by Publisher
 
The healing of a bone fracture is a biological process depending on the activation of mesenchymal progenitors, their accumulation in the fracture gap, proliferation and differentiation into the osteoblastic cell lineage. Its aim is to form a callus in the fracture gap which is later remodelled into mature bone, restoring the mechanical properties lost in consequence of the fracture.
Disturbances in fracture repair occur relatively often, causing therapeutic problems and increasing costs of treatment. They are caused by the lack of or damage to progenitor cells, disturbances in molecular regulation of their activation, homing, proliferation and differentiation into the osteoblastic cell lineage, or lack of appropriate environment for their optimal metabolism for fracture repair. This paper discusses the roles of individual factors crucial for the reparative process as well as the mechanisms responsible for their disturbances.

ICID 1186809

DOI 10.5604/15093492.1186809
PMID 26751744 - click here to show this article in PubMed
 
FULL TEXT 139 KB


Related articles
  • in IndexCopernicus™
         molekularna regulacja gojenia złamań [0 related records]
         zaburzenia zrostu kostnego [0 related records]
         złamanie kości [0 related records]
         factors stimulating bone union [0 related records]
         osteoblastic precursors [0 related records]
         molecular regulation of fracture repair [0 related records]
         fracture healing impairment [0 related records]
         bone fracture [2 related records]

  • Related articlesin PubMed database
  • in PubMed database [ related records]


  •  

    Copyright © Ortopedia Traumatologia Rehabilitacja  2017
    Page created by Index Copernicus Ltd. All Rights reserved.