Role of cathepsin K in the pathogenesis of degenerative changes in joints Kinga Lis, Grażyna Odrowąż-Sypniewska Ortop Traumatol Rehabil 2005; 7(4):361-364 ICID: 443324
Article type: Review article
IC™ Value: 5.33
Abstract provided by Publisher
Primary osteoarthritis is one of the oldest known joint diseases. The damage to the joint involves all its structures, and leads to considerable discomfort in daily life and limitations on patient activity. Degenerative changes within the joint were described in ancient time, but the mechanism has not yet been fully elucidated. Cleavage of collagens in the organic matrix of subchondral bone and cartilage by cysteine proteases, such as cathepsin K, may be one possible mechanism.
ICID 443324 PMID 17611453 - click here to show this article in PubMed