Newsletter
Language
Language:
 
News
Archival Issues
Volume 18, 2016
Volume 17, 2015
Volume 16, 2014
Volume 15, 2013
Volume 14, 2012
Volume 13, 2011
Volume 12, 2010
Volume 11, 2009
Volume 10, 2008
Volume 9, 2007
Volume 8, 2006
Volume 7, 2005
Volume 6, 2004
Volume 5, 2003
Volume 4, 2002
Volume 3, 2001
Volume 2, 2000
Volume 1, 1999
Search
 » 
Journal Abstract
 
Senescence of osteogenic cells. Review.
Krzysztof H Włodarski, Paweł K. Włodarski, Ryszard Galus
Ortop Traumatol Rehabil 2007; 9(1):63-67
ICID: 473691
Article type: Review article
IC™ Value: 5.70
Abstract provided by Publisher
 
In older individuals the regeneration of bone tissue is delayed due to the diminished activity of osteoblasts, while osteogenic potency of human bone marrow stromal cells, also capable of forming bone, does not change with age. The number of osteoprogenitor cells is not reduced in ageing subjects, but their proliferating rate and the activity of their derivatives--osteoblasts, is markedly diminished, since the self-renewing potential of these cells is hindered. The senescence of osteoblasts in ageing people is also accelerated. Changes within the bone marrow microenvironment reduce osteogenic potential of osteoprogenitor cells leading to impaired bone formation seen in senility, while the potency for ectopic osteogenesis does not change with age. This review summarizes documented mechanisms of changes in osteogenic activity of cells in elderly.

ICID 473691
PMID 17514176 - click here to show this article in PubMed
 
FULL TEXT 87 KB


Related articles
  • in IndexCopernicus™
         Bone Marrow [212 related records]
         Ageing [20 related records]
         osteoprogenitor cells [2 related records]

  • Related articlesin PubMed database
  • in PubMed database [ related records]


  •  

    Copyright © Ortopedia Traumatologia Rehabilitacja  2017
    Page created by Index Copernicus Ltd. All Rights reserved.