The undesirable side-effects of non-steroidal anti-inflammatory drugs Magdalena Hamera-Słynarska, Konrad Słynarski Ortop Traumatol Rehabil 2001; 3(1):126-128 ICID: 495677
Article type: Review article
IC™ Value: 2.71
Abstract provided by Publisher
Non-steroidal anti-inflammatory drugs (NSAD) are among the most commonly used medications. Many of them, such as ibuprofen, naproxen and aspirin, are widely advertised in the media and available without prescription. NSADs have anti-inflammatory effects, and some of them (aspirin, ibuprofen) are also antipyretic. The basic mechanism of their action is based on the inhibition of the enzyme cascade in the metabolism of arachidonid acid – cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) – and as a result inhibition of prostaglandin production. The undesirable side-effects of NSADs are primarily a direct result of the anti-inflammatory mechanism, and increase proportionally with the dosage. The article presents undesirable side-effects in the digestive system, the kidneys, and elsewhere. In conclusions the author point to the need for caution in using drugs of this kind.
ICID 495677 PMID 17986975 - click here to show this article in PubMed