LEPTIN AS A MODULATOR OF OSTEOGENESIS Krzysztof Włodarski, Paweł Włodarski Ortop Traumatol Rehabil 2009; 11(1):1-6 ICID: 879902
Article type: Review article
IC™ Value: 6.02
Abstract provided by Publisher
Leptin, a hormone secreted by adipose tissue, but also by several other tissues, has a dual effect on bone, acting by two independent mechanisms. As a signal molecule with growth factor characteristics, leptin is able to stimulate osteoblastic cells and to inhibit osteoclast formation and activity, thus promoting osteogenesis. However, as a molecule which stimulates sympathetic neurons in the hypothalamus, leptin indirectly inhibits bone formation. This inhibitory effect of leptin mediated by activation of sympathetic nervous system can be abrogated by application of blood pressure-reducing beta-blockers, which also inhibit receptors of hypothalamic adrenergic neurons.
ICID 879902 PMID 19240679 - click here to show this article in PubMed